‘ ‘ Regulation of chromosome stability by the histone H 2 A variant Htz 1 , the Swr 1 chromatin remodeling complex , and the histone acetyltransferase
نویسندگان
چکیده
CELL BIOLOGY. For the article ‘‘Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4,’’ by Nevan J. Krogan, Kristin Baetz, Michael-Christopher Keogh, Nira Datta, Chika Sawa, Trevor C. Y. Kwok, Natalie J. Thompson, Michael G. Davey, Jeff Pootoolal, Timothy R. Hughes, Andrew Emili, Stephen Buratowski, Philip Hieter, and Jack F. Greenblatt, which appeared in issue 37, September 14, 2004, of Proc. Natl. Acad. Sci. USA (101, 13513–13518; first published September 7, 2004; 10.1073 pnas. 0405753101), the authors note that in Fig. 3B, the panel referring to ‘‘eaf7 , 5 g ml Benomyl’’ was identical to ‘‘eaf5 , 5 g ml Benomyl’’ immediately above. The corrected figure and its legend appear below. This error does not affect the conclusions of the article. GENETICS. For the article ‘‘Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA,’’ by Ai Leen Lam, Christopher D. Boivin, Caitlin F. Bonney, M. Katharine Rudd, and Beth A. Sullivan, which appeared in issue 11, March 14, 2006, of Proc. Natl. Acad. Sci. USA (103, 4186–4191; first published March 6, 2006; 10.1073 pnas.0507947103), the authors note that the legend for Fig. 2 appeared incorrectly. The figure and its corrected legend appear below. This error does not affect the conclusions of the article.
منابع مشابه
P-209: Decreased Expression of Histone Acetyltransferase CDY1 Gene in Testis Tissue May Lead to Decreased Expression of Transition Protein (TNP) and Protamine (PRM) Genes,Causing Male Infertility
Background: Infertility is a complex medical problem. About 15% of couples are infertile, and male infertility being involved in roughly 50% of the cases. Among these, many cases are associated with a severe impairment of spermatogenesis. During the last stage of spermatogenesis (spermiogenesis), sperm chromatin endures complex modifications in which histones are lost and depositioned with tran...
متن کاملThe Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4.
The histone H2A variant H2A.Z (Saccharomyces cerevisiae Htz1) plays roles in transcription, DNA repair, chromosome stability, and limiting telomeric silencing. The Swr1-Complex (SWR-C) inserts Htz1 into chromatin and shares several subunits with the NuA4 histone acetyltransferase. Furthermore, mutants of these two complexes share several phenotypes, suggesting they may work together. Here we sh...
متن کاملP-217: Expression Analysis of The Histone Variant H2A.Z in Endometrium Tissue during The Menstrual Cycle
Background: The human endometrium undergoes cyclical changes including proliferation, differentiation, tissue breakdown and shedding (menstruation) throughout a woman’s reproductive life. The postovulatory rise in ovarian progestrone induces profound remodeling in chromatin structure of cells, and consequently differentiation of estradiol-primed endometrium. This change is crucial for embryo im...
متن کاملThe Genomic Distribution and Function of Histone Variant HTZ-1 during C. elegans Embryogenesis
In all eukaryotes, histone variants are incorporated into a subset of nucleosomes to create functionally specialized regions of chromatin. One such variant, H2A.Z, replaces histone H2A and is required for development and viability in all animals tested to date. However, the function of H2A.Z in development remains unclear. Here, we use ChIP-chip, genetic mutation, RNAi, and immunofluorescence m...
متن کاملNuA4-directed chromatin transactions throughout the Saccharomyces cerevisiae genome.
Two of the major histone acetyltransferases in Saccharomyces cerevisiae are NuA4 and SAGA, which acetylate histones H4 and H3, respectively. Acetylated H3 and H4 tails have been implicated in binding bromodomain proteins, including Bdf1. Bdf1 interacts with the general transcription factor TFIID, which might promote preinitiation complex (PIC) assembly. Bdf1 also interacts with the SWR complex ...
متن کامل